Children with Marfan, Loeys-Dietz, and VEDS: More than Medicine
41:01-43:07
So more to the point of why we're here. As I said I work not just in the connective tissue disorder clinic here but also amongst the few cardiac populations and this is kind of an important takeaway that I think, again if I meet somebody they say, "Oh, what do you do?" "Oh, I'm a psychologist at Stanford. I mostly work in cardiology." "Why are you in cardiology?" That's always the first question and I think it's, it's important to remember a few things here.
ではセミナーのテーマに移ります。自己紹介で申し上げたように、私は結合組織疾患のクリニックで勤務しているわけですが、そうした疾患の患者さんの中でも特に心疾患の患者さんに関わっています。他の方から職業を訊かれ、「スタンフォード大学で精神分析をしていますが、ほとんど循環器科の仕事をしています」 とお答えすると「なぜ循環器なのですか」と決まって訊き返されます。ここで皆さんに覚えておいていただきたいことがあるのです。
So one throughout the lifespan, lifespan cardiac dysfunction will really impact brain structure and functioning and that's true of, certainly, of congenital heart disease and there's even within some of the populations I see, like the single ventricle population, very specific ways that, that often shakes out but as Alan pointed out, not, it's not deterministic, there's a lot, there's still a great deal of variability. But even aging, the untreated the two highest risk factors for dementia are not genetics, not bad luck. It's high blood pressure followed by high cholesterol
生涯に渡って心疾患をお持ちの方では、脳の構造や脳機能に影響があります。先天性心疾患の方はもちろんですが、単心室症の方の一部でも、精査が必要ではありますが、そうした影響があるとされています。Alan先生のご指摘どおり、確定的な情報ではなく、ばらつきが非常に大きいことはご承知おきください。また、加齢に伴い、未治療のまま放置することで認知症に至るリスクのトップ2は、遺伝的素因でも、運でもありません。高血圧がトップで、2位が高コレステロール血症となっています。
And so it's really important to kind of take into account, how important the heart really is for our brain functioning. They also develop step in step so congenital heart issues may also have congenital brain issues and there again that's a different topic for a different day.
このように心臓は脳機能にとって非常に重要であり、先天的な心臓の病気が徐々に先天的な脳の問題に進行するということもあります。
But I also think it's important to remember even if we don't have a cardiac condition the brain is greedy. It is a greedy jerk. It, it takes out about two percent of someone's total body weight but consumes 20 of the oxygen, glucose and blood supply and I mean you've probably experienced this. If you've ever been kind of hard at work and maybe not eating or you've just had a big lunch, you get hard at work at something you're really kind of straining your brain a little bit and you're like, "There's no way I could be hungry again. I just ate." But sure enough you can get hungry quite quick from something as simple as thinking deeply.
また、心臓の病気とは関係なく、脳は大量にエネルギーを消費します。脳の重さは体重の2％ほどですが、体内にある酸素、ブドウ糖、血液量の20％を消費します。心当たりがあるかと思いますが、食事せずに頑張って働いた後でも、昼食をたくさん食べた後で脳を酷使するような作業をした後でも、空腹を感じます。深く考えるといった単純な作業でもこのような状態になるのです。
The Marfan Foundation did not participate in the translation of these materials and does not in any way endorse them. If you are interested in this topic, please refer to our website, Marfan.org, for materials approved by our Professional Advisory Board.
The Marfan Foundation は、当翻訳には関与しておらず、翻訳内容に関してはいかなる承認も行っておりません。このトピックに興味をお持ちの方は、Marfan.org にアクセスし、当協会の専門家から成る諮問委員会が承認した内容をご参照ください。
