COVID-19 and Marfan/VEDS/LDS: Your Questions Answered
1:07:51-1:11:07
So these are questions that deal with lung issues and this virus, so Enid?
このスライドの質問は肺に関するものですので、Enid先生お願いします。
Yeah, these we covered some of these, I think, in, in the prior slides but I want the listeners to be clear about is the fact that the lung involvement is very much tied to this infection.
一部はすでに説明しましたが、この感染症は肺と密接な関係があるということをご理解いただきたいと思います。
And that is because the virus actually binds to a protein that is present on the lining of the lungs, that what we call the lung epithelium, and that's not unusual because there are other respiratory viruses who bind to other proteins in order to enter the cell.
このウイルスは肺上皮と呼ばれる部分に存在するタンパク質に結合します。他の呼吸器系のウイルスも別のタンパク質に結合することで細胞内に入り込みますので、特に珍しいことではありません。
But what's helpful to think about is that a virus has agenda and that agenda is to produce more variance to expand to proliferate and the way that it does it is by entering the cell and using the cells on machinery to produce more viruses and then, killing the cell so that the cell releases kind of all of these kind of progeny of the virus. And so in the lung the immediate effects of that is that the cells that lining kind of the lungs are compromised and are lost.
ウイルスには増殖のためにより多くの変異体を作り出すという目的があります。そのために細胞の仕組みを使って仲間を作り出し、細胞を死滅させて拡散していきます。この結果、肺の細胞が傷つき死滅してしまいます。
And in someone who has kind of the normal ability to repair the lung, they can tolerate this and there will be shortness of breath and there will be a cough and there will be an inflammatory response but that will resolve over time and there won't be severe complications of kind of their lung function.
息切れや咳、炎症反応が起きますが、肺が正常の方では時間が経過すると回復し、重篤な合併症は起きません。
But in the event that, that repair doesn't take place efficiently and that is one of the concerns that we have with the variety of lung disorders, many of which were on that list and we have a specific concern in patients who have connective tissue disorders because one of the ways that the lung and other organs repair itself is by using the connective tissue almost like a template or as a guide in order to repair and to replace cells.
ですが、肺の修復がきちんと行われない場合には、様々な肺疾患を抱える方では問題となります。結合組織をひな形として細胞の修復や入れ替えが行われるため、結合組織疾患のある方では、特に問題となります。
And in the event that repair doesn't happen and that leads to kind of ongoing respiratory compromise, the need for some type of a ventilatory support, maybe a ventilator and can actually cause kind of ultimate death.
肺の修復が行われない場合、肺の損傷が続き、人工呼吸器が必要となったり、死亡に至ることがあります。
And so when you have an underlying lung issue, we're not worried as much about whether you will be infected. We're worried about the fact that an infection will have much more serious consequences in your situation than it would in someone who doesn't have these underlying lung issues.
そのため、肺の基礎疾患がある方については、感染するかどうかはそれほど問題ではなく、感染した場合には、かなり重篤な症状となることが懸念されます。
You're not more susceptible to COVID but you will have potentially many more complications of a COVID infection.
マルファン関連疾患の方がCOVID-19にかかりやすいというわけではなく、感染した際に多くの合併症のリスクがあるということです。
The Marfan Foundation did not participate in the translation of these materials and does not in any way endorse them. If you are interested in this topic, please refer to our website, Marfan.org, for materials approved by our Professional Advisory Board.
The Marfan Foundation は、当翻訳には関与しておらず、翻訳内容に関してはいかなる承認も行っておりません。このトピックに興味をお持ちの方は、Marfan.org にアクセスし、当協会の専門家から成る諮問委員会が承認した内容をご参照ください。
