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Marfan Basics: Taking Care of Your Aorta 1:16:41-1:19:21 So, our studies have shown that athletic activity after diagnosis is possible. There are even people doing competitive athletic activities―these are not officially sanctioned, but th…
Marfan Basics: Taking Care of Your Aorta 1:15:46-1:16:40 So, during our clinical trial, we found that people did generally very well, but the number of, um, kind of problems they had during exercise seemed to be directly related to the num…
Marfan Basics: Taking Care of Your Aorta 1:10:11-1:12:20 And so the two kinds of medications we recommend are ARBs or Angiotensin receptor blockers, which you probably have heard of, like Losartan, and beta blockers, like Metoprolol or Ate…
Marfan Basics: Taking Care of Your Aorta 1:09:33-1:10:09 So, again, before starting exercise, it's really important to make sure that your blood pressure is controlled. This is from the guidelines. We typically say, you know, for high bloo…
結合組織疾患における全般的な消化器の懸念 結合組織疾患患者で最も一般的な消化器の問題とは？ 診断と治療法 専門医にかかるべきタイミング、サイン、専門知識のある医師や医療機関を受診することの重要性について 標準的な消化器の薬（例 プロトンポンプ阻…
この資料は、感染性心内膜炎の予防のための抗生物質投与ガイドライン、特に2007年4月に改訂された米国心臓協会（AHA）のガイドラインについて説明しています。また、マルファン症候群の患者に対する推奨にも触れています。 米国心臓協会（AHA）ガイドライン…
Managing HTAD: Key Insights from the 2024 ESC Guidelines 1:07:34-1:10:43 Q: Is the use of ARBs recommended in Marfan patients whose blood pressure is normal to low and this person has a abdominal aneurysm which is followed annually and the…
Managing HTAD: Key Insights from the 2024 ESC Guidelines 1:03:09-1:05:28 Q: Are there side effects that come from losartan? Julie? ロサルタンの副作用はありますか？ A: Yeah, I can go on. Side effects from the main... the main concern is tha…
Managing HTAD: Key Insights from the 2024 ESC Guidelines 59:57-1:03:02 Q: There is a question here about Celiprolol not being available in the United States, but currently, you can go into a trial with Celiprolol within the United States. …
Managing HTAD: Key Insights from the 2024 ESC Guidelines 42:12-43:27 Furthermore, for medical therapy, we advise Losartan, and why is this the case? This was a study done already in 2006, where it was shown that in mice, if you look at the…
Managing HTAD: Key Insights from the 2024 ESC Guidelines 29:24-32:57 To end, I would like to spend a few words on pregnancy because we also have some recommendations there. Data on pregnancy and heritable thoracic aortic disease so far hav…
Managing HTAD: Key Insights from the 2024 ESC Guidelines 28:35-29:22 Talking about medical treatment briefly, so Marfan syndrome, there's evidence in Marfan syndrome for beta blockers or an angiotensin receptor blocker (ARB), so losartan a…
Tromsø Aorta 2024 Recap with Dr. Kim Eagle 59:25-1:00:40 Q: Was there any discussion about the benefits of different *-sartans for Marfan at the conference? マルファン症候群に対する、ARB（ロサルタン以外）の効果に関する発表はありましたか？ …
Tromsø Aorta 2024 Recap with Dr. Kim Eagle 38:45-39:18 Q: There's a question here about would warfarin change D-dimer levels. ワーファリンはDダイマーに影響しますか？ A: Well, that's a great question. Anti-coagulation, by virtue of the fact…
Tromsø Aorta 2024 Recap with Dr. Kim Eagle 13:03-15:02 One of the really interesting talks that we heard in Tromsø was a trial that is looking at the management of patients with vascular EDS. This was a small study, I think less than 60 pa…
Applying AHA's 2024 Scientific Statement: Navigating Diagnosis & Management of Pediatric Aortopathy 52:50-54:51 Q: In the statement, you mentioned dual therapy if tolerated. What does "if tolerated" mean? What are indicators to change medi…
Applying AHA's 2024 Scientific Statement: Navigating Diagnosis & Management of Pediatric Aortopathy 51:52-52:44 Q: Is atenolol the preferred treatment for children four and under? 4歳以下の小児については、アテノロールのほうが好ましいですか…
Applying AHA's 2024 Scientific Statement: Navigating Diagnosis & Management of Pediatric Aortopathy 43:21-43:53 Q: What age should Losartan be started or is it just based on z-score? ロサルタンは何歳から飲み始めればいいでしょうか？それとも…
Applying AHA's 2024 Scientific Statement: Navigating Diagnosis & Management of Pediatric Aortopathy 13:02-15:02 And so for all of these slides, what we do is we basically provide a framework for how to manage patients, and this framework n…
Navigating GI Management in LDS 49:38-51:39 Q: You mentioned that steroids could be harmful for bones. Do the benefits outweigh risks if using steroids to treat asthma or EoE? ステロイドを服用すると骨への悪影響の可能性があるというお話があ…
Navigating GI Management in LDS 41:49-42:46 Q: Do you have a recommended NSAID that we could keep on hand for general use and if there's a recommendation for pediatrics versus adult patients? 日常的にそばに置いておくNSAIDのお勧めはあります…
Navigating GI Management in LDS 39:40-41:46 Q: Doctors are quick to recommend NSAIDs for different problems related to inflammation that is seen in people with connective tissue conditions, people with LDS. However, we understand that chro…
Investigation of Sleep Disorders and Lung Injury in Marfan Syndrome 9:36-13:34 Now several years ago when I was working in the Dietz’s lab we showed that the enlarged airspaces in the Marfan lung was caused by developmental perturbations o…
Medical Management of Marfan Syndrome 54:54-57:10 So let's go go back to the take-home messages. What I would like to to convey is that there is now a very substantial evidence base for good medical treatment for patients with Marfan syndr…
Medical Management of Marfan Syndrome 53:29-54:53 This is a bit more controversial perhaps. There are a group of medications called triptans. These are used for migraine and usually used as, as an acute treatment. They're not used for prev…
Medical Management of Marfan Syndrome 52:14-53:28 The, the next thing I want to bring to your attention is that there are medications called calcium channel blockers. These are medications like verapamil, diltiazem, things like that. They'…
Medical Management of Marfan Syndrome 48:55-52:09 I'm going to just talk about a couple of other issues now. There is and the, in particular I want to talk about the medications that we should not be giving and I'm sorry I'm running a bit …
Medical Management of Marfan Syndrome 48:17-48:54 So I'm now going to just skip forward and just draw some conclusions from the trials. So angiotensin receptor blockers reduce the rate of aortic growth in Marfan syndrome. The effects of AR…
Medical Management of Marfan Syndrome 44:21-48:07 I'm just going to go back and say that we were able to explore, you know, one of the questions was, you know, was there evidence that these medications reduced the rate of tearing of the ao…
Medical Management of Marfan Syndrome 42:43-44:20 And then, we, then went on to look at trials where they had compared angiotensin receptor blockers with beta blockers. This is a different kind of trial. ARB versus beta blockers head-to-he…
