Medical Management of Marfan Syndrome
53:29-54:53
This is a bit more controversial perhaps. There are a group of medications called triptans. These are used for migraine and usually used as, as an acute treatment. They're not used for prevention of migraine. They're used to terminate a, a, an episode of migraine. They cause blood vessels to constrict and can cause rises in blood pressure and the data for this I think is very sparse but I have definitely heard of and have met small numbers of patients who have had migraines or they think is a migraine, they've taken a tablet, a triptan medication and then within an hour or two of, of have that, having happened, they have had aortic dissections.
トリプタン系の薬については、賛否両論あります。この系統の薬は通常、偏頭痛の急性治療に用いられます。偏頭痛の予防には用いられません。血管を収縮させますので、血圧が上昇します。わずかなデータしかありませんが、偏頭痛であると訴えた少数の患者さんで、トリプタン系の薬を飲み、その1、2時間後に大動脈解離を発症したというケースを実際に見聞きしたことがあります。
Now these are very small isolated reports. This is not strong evidence but, you know, I've heard, have heard enough to make me anxious about it and I think other colleagues have had similar experiences. It's a little bit difficult to be certain about it. Maybe were those symptoms, they were experiencing perhaps not migraines and actually the first symptoms of aortic tearing something like that.
非常に稀な報告であり、信頼に足るエビデンスではありませんが、私自身不安を覚えていることは確かであり、他の先生方も同様の経験をお持ちだと思います。この薬については確証を持てずにいます。先ほどの患者さんが経験したのは偏頭痛ではなく、大動脈解離の初期症状のようなものだった可能性もあります。
So I'm not sure about it but I would prefer for patients like that to be on medications to prevent their migraines from happening in the first place rather than maybe taking medications to terminate the attack. That would be a better strategy, so I try to avoid triptan wherever I can.
はっきりと結論を申し上げることはできないのですが、偏頭痛をお持ちの患者さんについては、第一に偏頭痛を予防するような薬を服用するようにし、トリプタン系の薬で症状を抑えることはしないほうが良いのではないかと考えます。こちらの方が戦略としては優れていると思いますし、私自身トリプタン系の薬の処方は控えるようにしています。
The Marfan Foundation did not participate in the translation of these materials and does not in any way endorse them. If you are interested in this topic, please refer to our website, Marfan.org, for materials approved by our Professional Advisory Board.
The Marfan Foundation は、当翻訳には関与しておらず、翻訳内容に関してはいかなる承認も行っておりません。このトピックに興味をお持ちの方は、Marfan.org にアクセスし、当協会の専門家から成る諮問委員会が承認した内容をご参照ください。
