Entries from 2020-11-01 to 1 month
Keeping Your Spine, Limbs, and Feet Healthy in Marfan and Related Conditions 3:51-4:42 On the spine, I'd like to cover scoliosis, kyphosis and slipping, spondylolisthesis. I think that these are all things you've probably heard of, but I'l…
Keeping Your Spine, Limbs, and Feet Healthy in Marfan and Related Conditions 3:04-3:50 The topic of my talk is to talk about their healthy limb, feet and spine and cooperating with Adam, we, the thing I'd like to focus on would be the spin…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit Q:Is there any more research being planned on the effects of losartan on other organ systems? 血管以外の臓器系に対してロサルタンの影響を調べる研…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 53:13-55:55 Final slide, there's lots of good work trying to identify other sources of modification of Marfan syndrome, making it worse or making…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 52:17-53:12 So based upon this, based upon both our hypothesis constrained arduous work but also now by this new technology of mapping modifiers,…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 49:29-53:12 We also found that losartan is tremendously protective even in these 129 mice, so it completely prevented aneurysms from forming and …
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 47:32-49:29 Now around the same time, we recognize that one strain of mouse called the black six (BL6) mouse had very mild aneurysms when we intr…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 43:49-47:31 So fortunately in collaboration with Bart Loeys, Anne De Peapa and Julie DeBacker and others, we've had the good fortune of observing…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 40:30-43:48 And one method to do this was to try to understand families with Marfan syndrome like the one that I'm showing here. 先ほど述べた従来…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 38:20-40:29 So I'm going to end the talk by talking about studying modifiers. 最後は、遺伝子の修飾についてお話します。 So over the course of the …
運動はマルファン症候群の方にも効果があります マルファン症候群では運動に修正が必要なのはなぜか？ 運動の種類 METs（代謝当量）とは？ マルファン症候群の方が運動する際に知っておくべきこと 医師が気にかけることは？ マルファン症候群の方が安全に運…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 36:57-38:19 It's clear that the ability to make stem cells has already led to significant advances. We're not quite ready to use them therapeutic…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 35:59-36:55 Now there are also some further advanced methods using stem cells that might be applicable to Marfan syndrome. 幹細胞を使った方法にも…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 34:03-35:57 We're also considering how we might deliver this activation machinery to the aorta and specifically to the base of the aorta, the so-…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 32:07-34:06 Now it turns out that there is a fetal form of fibrillin-1, it's a protein called fibrillin-2, just as we've been discussing, it norm…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 29:36-32:06 So I'm going to now tell you about what I think might be a an exciting twist on this type of therapeutic intervention. これまでに述べ…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 27:16-29:35 So what about Marfan syndrome? Let's consider what we have to achieve. Our target tissues are: the arterial system, you know, again w…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 24:29-27:15 So liver is really the poster child for cell and vector-based therapies. Why is liver so promising? 肝臓は細胞ベースの治療やベクター…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 23:25-24:28 So a lot of the same considerations for this genome editing inside the body. 体内でゲノム編集を行う場合も同様に、以下のような課題があ…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 20:52-23:24 So the easiest solution to imagine for this type of situation is that it's sufficient to have a blob of corrected cells that go somew…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 18:25-20:50 Now the final step is to put those cells back and expect them to do something good to not cause mischief but rather to benefit the pa…
CRISPR, Stem Cells, Gene Modifiers – The Future of Marfan Research (August 27 2020) E3 Summit 16:58-18:24 So once, but if you're starting with a culture dish in a lab and you're doing this correction process, even if only one percent of th…
