26:27-26:59
Just as a reminder, you know, there is overlapping severity in all different types of Loeys-Dietz syndrome, kind of big picture in general. What we kind of say is TGFBR1 and 2 tend to, as a whole, be on the more aggressive end of the spectrum. With SMAD3 kind of overlapping in the middle and then milder on TGFB2 and SMAD2 but this is definitely not a hard and fast rule and we have some families that overlap into the more severe category in Loeys-Dietz five and six and vice versa with TGFBR1 and 2.
LDSでは一般に、異なるタイプ同士で重症度に重なりがみられます。LDS1型および2型は全体的に最も高い重症度と考えられますが、これらの型とLDS3型とは大きな重なりがみられます。LDS4型、5型では重症度はより低くなります。とはいえ、これらは厳格なルールというわけではなく、LDS5型、6型の、より重症度が高いご家族もいれば、逆に、LDS1型、2型でも軽度の症状ということもあります。
The Marfan Foundation did not participate in the translation of these materials and does not in any way endorse them. If you are interested in this topic, please refer to our website, Marfan.org, for materials approved by our Professional Advisory Board.
The Marfan Foundation は、当翻訳には関与しておらず、翻訳内容に関してはいかなる承認も行っておりません。このトピックに興味をお持ちの方は、Marfan.org にアクセスし、当協会の専門家から成る諮問委員会が承認した内容をご参照ください。
