Dental Concerns of Marfan Syndrome (Virtual Medical Symposium Series - 01-16-2020)
7:28-10:23
So we think of Marfan syndrome, as, as it's defined as a genetic disorder and I'm not going to go over this exclusively.
マルファン症候群は遺伝性疾患と定義されていますが、このセミナーではそのことに特化してお話することはしません。
But I do want to sort of elevate the point that I am a clinician scientist so I happen to have a PhD in genetics and molecular biology and I like to think about things as having a genetic origin and, when possible, to be able to tie what I see clinically to that. I haven't had so much opportunity to do that, genotype-phenotype correlation work, yet but I'm, also I'm always mindful of that.
私は遺伝学と分子生物学のPhDを取得していますので、臨床医であると同時に科学者でもあり、遺伝的な要因がある場合には、それを臨床像と結びつけたいと考えています。これまで遺伝子型と表現型との相関に関する研究を多く行う機会があったわけではありませんが、そのことについては常に関心があります。
And as, you know, Marfan syndrome is a multi-system disorder and I say this not because you need to hear it and you don't know it but because I want to etch this in your brain that when we think about dentistry, we're thinking about the musculoskeletal system.
マルファン症候群は多くの器官に関わる疾患です。こう述べたのは皆さんにそのことをわかってもらいたいからではありません。歯科は筋骨格系として捉える必要があることをわかってもらいたいからです。
The things that we think about aren't often teeth or the face and dentistry but when you look at the musculoskeletal presentation, it does include things that we know more, which is the disproportionately tall, thin stature and some other things, but there's also, this is where dental falls, it falls within that skeletal realm and frankly, regardless of whether this is a major criteria or not because it is not, the face is not, but we know that most of us feel that we can detect marfan or marfanoid features just from looking at the face.
マルファン症候群の特徴で思いつくのは、多くの場合、歯や顔面のことではなく、やせ型で背が高いといったことですが、実は歯は骨格系の特徴に分類されます。実際のところ、顔面はマルファン症候群の診断基準には入っていませんが、我々専門家の多くはマルファン症候群やマルファン的特徴は、顔を見るだけでわかると考えています。
And what else? We also know that there are other aspects of the musculoskeletal system that may be relevant to dentistry. Again we tend to think about feet or hands, other joints but joint hyper-mobility has a strong correlation to the joint that helps you when you're chewing your food, the temporomandibular joint, so we'll touch on that just a little bit.
その他にも、歯科に関連する骨格的な特徴があることがわかっています。足や手、関節などではありません。関節の柔らかさは、ものを噛むときの関節である顎関節に関連します。これについては後で触れたいと思います。
And we also know that even though the cardiovascular system seems like, it wouldn't have anything to do with teeth, what we know is that depending on the health and condition of your cardiovascular system, you may be more prone to an infective endocarditis and there's a strong correlation with the microbes or sort of flora in your mouth and the potential for that to have an impact when those that have some cardiovascular conditions, that predispose them to infective endocarditis.
心血管系は歯科とは無縁だと思われるかもしれませんが、心臓や血管の状態によっては、感染性心内膜炎に罹患するリスクが高まります。口腔内の細菌叢と強い関連があり、心血管系の疾患がある場合には、細菌の影響で発症しやすくなります。
The Marfan Foundation did not participate in the translation of these materials and does not in any way endorse them. If you are interested in this topic, please refer to our website, Marfan.org, for materials approved by our Professional Advisory Board.
The Marfan Foundation は、当翻訳には関与しておらず、翻訳内容に関してはいかなる承認も行っておりません。このトピックに興味をお持ちの方は、Marfan.org にアクセスし、当協会の専門家から成る諮問委員会が承認した内容をご参照ください。
